Hager Marlene, Ott Johannes, Castillo Deirdre Maria, Springer Stephanie, Seemann Rudolf, Pils Sophie
Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
Clinical Division of Obstetrics and Fetomaternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
J Clin Med. 2020 May 18;9(5):1523. doi: 10.3390/jcm9051523.
Over the last decades, there has been a substantial increase in the incidence of higher-order multiple gestations. Twin pregnancies are associated with an increased risk of gestational diabetes mellitus (GDM). The literature on GDM rates in triplet pregnancies is scarce.
A retrospective cohort study was performed to assess the prevalence of GDM in women with a triplet pregnancy. GDM was defined through an abnormal oral glucose tolerance test (OGTT). A meta-analysis of GDM prevalence was also carried out.
A cohort of 60 women was included in the analysis. Of these, 19 (31.7%) were diagnosed with GDM. There were no differences in pregnancy outcomes between women with and without GDM. In the meta-analysis of 12 studies, which used a sound GDM definition, an estimated pooled prevalence of 12.4% (95% confidence interval: 6.9%-19.1%) was found. In a leave-one-out sensitivity analysis, the estimated GDM prevalence ranged from 10.7% to 14.1%.
The rate of GDM seems increased in women with triplets compared to singleton pregnancies. However, GDM did not impact short-term pregnancy outcomes.
在过去几十年中，高阶多胎妊娠的发生率大幅上升。双胎妊娠与妊娠期糖尿病（GDM）风险增加相关。关于三胎妊娠中GDM发生率的文献较少。
进行了一项回顾性队列研究，以评估三胎妊娠女性中GDM的患病率。通过异常口服葡萄糖耐量试验（OGTT）定义GDM。还对GDM患病率进行了荟萃分析。
分析纳入了60名女性队列。其中，19名（31.7%）被诊断为GDM。患GDM和未患GDM的女性妊娠结局无差异。在对12项使用合理GDM定义的研究进行的荟萃分析中，估计合并患病率为12.4%（95%置信区间：6.9%-19.1%）。在逐一剔除敏感性分析中，估计的GDM患病率范围为10.7%至14.1%。
与单胎妊娠相比
