NRF2/KEAP1 轴在肿瘤代谢调控中的作用：机制与治疗展望。
The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives.
机构信息
Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Department of Medical Biology, Faculty of Medicine, Yuksek Ihtisas University, 06520 Balgat, Ankara, Turkey.
出版信息
Biomolecules. 2020 May 20;10(5):791. doi: 10.3390/biom10050791.
The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in recent years has indicated that metabolic reprogramming is closely interrelated with the regulation of redox homeostasis, suggesting that the disruption of NRF2 signaling might represent a valid therapeutic strategy against a variety of solid and hematologic cancers. These aspects will be the focus of the present review.
NRF2/KEAP1 通路是一种基本的信号级联反应，通过诱导复杂的转录程序来控制多种细胞保护反应，最终使癌细胞对氧化、代谢和治疗压力产生抗性。有趣的是，近年来积累的证据表明，代谢重编程与氧化还原平衡的调节密切相关，这表明 NRF2 信号的中断可能代表针对各种实体瘤和血液系统恶性肿瘤的有效治疗策略。这些方面将是本综述的重点。
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