Direct Oral Anticoagulants in Obesity: An Updated Literature Review.

OBJECTIVE

To review literature on the use of direct-acting oral anticoagulants (DOACs) in patients with high body weight (BW) and/or high body mass index (BMI) and to make recommendations regarding use in this patient population.

DATA SOURCES

A search using PubMed was conducted (inception to April 13, 2020) using the term AND the terms OR . A separate search was also conducted with individual DOACs (dabigatran, apixaban, rivaroxaban, edoxaban) and the aforementioned terms.

STUDY SELECTION AND DATA EXTRACTION

Studies included examined the effect of BW and/or BMI on DOAC pharmacokinetics, efficacy, or safety. Included studies had DOAC indications of prevention of stroke in nonvalvular atrial fibrillation, or treatment or long-term prevention of venous thromboembolism.

DATA SYNTHESIS

The efficacy and safety of DOACs in patients with high BW/BMI has not yet been elucidated by randomized trials; however, 2016 international guidelines suggest avoiding their use in patients with a BW >120 kg or BMI >40 kg/m. Since 2016, several studies have been published examining use of DOACs in this patient population.

RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE

This review thoroughly discusses the literature on DOACs in patients with a BW >120 kg or BMI >40 kg/m pre-2016 and post-2016 guidelines.

CONCLUSIONS

Evidence indicates that each DOAC may have differences in outcomes when used in patients with a high BW/BMI. Currently, low-quality data are available that support avoiding dabigatran and considering apixaban or rivaroxaban; lack of sufficient data preclude a recommendation for edoxaban use in this patient population.