Physiology Research Center, Institute of Basic and Clinical Physiology & Department of Nutrition, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Department of Nutrition, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Complement Ther Med. 2020 May;50:102391. doi: 10.1016/j.ctim.2020.102391. Epub 2020 Apr 8.
The purpose of this up-to-date comprehensive systematic review was to evaluate and summarize all research studies in the field in order to clarify the magnitude of Nigella sativa (N. sativa) effects on the management of Diabetes mellitus (DM) and its complications.
A systematic review was conducted in a Cochrane style and in accordance PRISMA checklist using the published studies in PubMed/MEDLINE, SCOPUS, and EMBASE databases that were searched up to January 2019. Abstracts that met PICO criteria for qualitative studies underwent dual review for data extraction to evaluate study quality and details.
Dietary supplementation with N. sativa preparations can improve various secondary complications of diabetic patients. N. sativa preparations possess antidiabetic, hypoglycemic, anti-hyperlipidemic, antihypertensive, and anti-obesity effects. Beneficial effects of N. sativa preparations include the restoration of the antioxidant defense systems, the increase in the activity of antioxidant enzymes, the decrease of inflammatory biomarkers, the suppression of the production pro-inflammatory mediators, improvement of endothelial dysfunction, and hepatic, kidney, heart and immune system functions. They have key roles in managing diabetes-induced inflammation and oxidative stress in diabetic patients.
N. sativa preparations have key roles in herbal medicine as an adjuvant in the treatment and management of patients with DM and its complications. Moreover, the beneficial effects of N. sativa preparations were differently based on dosage forms, active ingredients, and duration of intervention. The best dosage to improve glycemic indices and lipid and lipoprotein profiles is 2 g daily powdered N. sativa for at least 12 weeks.
本最新全面系统评价旨在评估和总结该领域的所有研究，以明确黑种草（N. sativa）对糖尿病（DM）及其并发症管理的影响程度。
按照 Cochrane 风格和 PRISMA 清单进行系统评价，使用已发表的在 PubMed/MEDLINE、SCOPUS 和 EMBASE 数据库中搜索的研究，检索截至 2019 年 1 月。符合定性研究 PICO 标准的摘要进行双重审查，以进行数据提取，评估研究质量和细节。
黑种草制剂的膳食补充可改善糖尿病患者的各种次要并发症。黑种草制剂具有抗糖尿病、降血糖、抗高血脂、降血压和抗肥胖作用。黑种草制剂的有益作用包括恢复抗氧化防御系统、增加抗氧化酶活性、降低炎症生物标志物、抑制促炎介质的产生、改善内皮功能障碍以及改善肝脏、肾脏、心脏和免疫系统功能。它们在管理糖尿病患者的炎症和氧化应激方面起着关键作用。
黑种草制剂在草药学中作为 DM 及其并发症患者治疗和管理的辅助药物具有关键作用。此外，黑种草制剂的有益作用因剂型、活性成分和干预持续时间而异。改善血糖指数和血脂及脂蛋白谱的最佳剂量为每天 2 克粉状黑种草，至少干预 12 周。
