Rahmani Alireza, Niknafs Bahram, Naseri Mohsen, Nouri Maryam, Tarighat-Esfanjani Ali
Student Research Committee, Student Research Center, Tabriz University of Medical Sciences, Tabriz, IR, Iran.
Department of Internal Medicine, School of Medicine, Imam Reza Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, IR, Iran.
Evid Based Complement Alternat Med. 2022 Apr 15;2022:2753294. doi: 10.1155/2022/2753294. eCollection 2022.
Diabetes is a leading cause of renal failure. High levels of oxidative stress and inflammation in patients with renal diabetes lead to various disorders and mortality. This study was performed to determine the effect of Nigella sativa (NS) supplementation on superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), high-sensitivity C-reactive protein (hs-CRP), glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and insulin (INS) in patients with diabetes mellitus undergoing hemodialysis (HD).
In this randomized, double-blind, placebo-controlled clinical trial, a total of 46 diabetic HD patients were randomly divided into NS ( = 23) and placebo ( = 23) groups. NS group received 2 g/day of NS oil, and the placebo group received paraffin oil for 12 weeks. Serum levels of SOD, MDA, TAC, hs-CRP, HbA1C, FBS, and INS were measured before and after the study.
Compared to baseline values, SOD, TAC, and INS levels increased, whereas MDA, hs-CRP, HbA1c, and FBS significantly decreased. After adjusting for covariates using the ANCOVA test, changes in the concentrations of SOD ( = .040), MDA ( = .025), TAC (=<.001), hs-CRP ( = .017), HbA1c ( = .014), and FBS ( = .027) were statistically significant compared to the placebo group. Intergroup changes in INS were not significant. Additionally, there were no notable side effects during the research.
This study found that NS supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic HD patients.
糖尿病是肾衰竭的主要原因。糖尿病肾病患者体内高水平的氧化应激和炎症会导致各种疾病和死亡。本研究旨在确定补充黑种草（NS）对接受血液透析（HD）的糖尿病患者超氧化物歧化酶（SOD）、丙二醛（MDA）、总抗氧化能力（TAC）、高敏C反应蛋白（hs-CRP）、糖化血红蛋白（HbA1c）、空腹血糖（FBS）和胰岛素（INS）的影响。
在这项随机、双盲、安慰剂对照的临床试验中，共46例糖尿病HD患者被随机分为NS组（n = 23）和安慰剂组（n = 23）。NS组每天服用2 g NS油，安慰剂组服用石蜡油，持续12周。在研究前后测量血清中SOD、MDA、TAC、hs-CRP、HbA1C、FBS和INS的水平。
与基线值相比，SOD、TAC和INS水平升高，而MDA、hs-CRP、HbA1c和FBS显著降低。使用协方差分析（ANCOVA）检验调整协变量后，与安慰剂组相比，SOD（P = 0.040）、MDA（P = 0.025）、TAC（P＜0.001）、hs-CRP（P = 0.017）、HbA1c（P = 0.014）和FBS（P = 0.027）浓度的变化具有统计学意义。组间INS变化不显著。此外，研究期间没有明显的副作用。
本研究发现，补充NS可显著提高糖尿病HD患者的SOD、MDA、TAC、hs-CRP、HbA1c和FBS水平。
