King's College London, Department of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, United Kingdom.
Parkinson Foundation Centre of Excellence, King's College Hospital, Denmark Hill, London, United Kingdom.
J Parkinsons Dis. 2020;10(3):1003-1010. doi: 10.3233/JPD-201988.
Previous studies have identified low serum uric acid (SUA) levels as a risk factor for the development of Parkinson's disease (PD). Prodromal PD mainly manifests as a complex of non-motor features, but the association between SUA levels and nonmotor symptoms (NMS) burden level in advanced PD patients is poorly studied.
To determine the association between SUA levels and NMS in PD patients.
Data were gathered from an open label, cross sectional, study with analysis of SUA levels in 87 PD patients and were correlated to NMS through the NMS scale (NMSS). In addition, we examined the possible relation between SUA and NMS burden levels and motor scores.
There was a moderate negative association between SUA levels and NMSS total score (ρ= -0.379, p < 0.001). In line with this, we observed that higher NMS burden was associated with lower SUA levels (p < 0.001). Within individual NMSS domains, a moderate negative correlation was observed between SUA levels and the cardiovascular/falls (ρ= -0.285, p = 0.008), sleep/fatigue (ρ= -0.299, p = 0.005), and miscellaneous domains (ρ= -0.318, p = 0.003).
In this observational study we observed that SUA levels were negatively associated to NMS burden in PD patients with a specific link to miscellaneous, sleep/fatigue and cardiovascular domains of the NMSS. Interestingly, we did not find a clear relation between SUA and motor scores. Future large-scale prospective studies in de novo and advanced PD are needed to evaluate and establish these associations.
先前的研究已经确定血清尿酸（SUA）水平低是帕金森病（PD）发展的危险因素。前驱期 PD 主要表现为一系列非运动特征，但 SUA 水平与晚期 PD 患者非运动症状（NMS）负担水平之间的关联尚未得到充分研究。
确定 SUA 水平与 PD 患者 NMS 之间的关系。
这项开放标签、横断面研究中收集了 87 例 PD 患者的 SUA 水平数据，并通过 NMS 量表（NMSS）将其与 NMS 相关联。此外，我们还检查了 SUA 与 NMS 负担水平和运动评分之间可能存在的关系。
SUA 水平与 NMSS 总分呈中度负相关（ρ=-0.379，p<0.001）。与此一致的是，我们观察到较高的 NMS 负担与较低的 SUA 水平相关（p<0.001）。在 NMSS 的各个领域中，SUA 水平与心血管/跌倒（ρ=-0.285，p=0.008）、睡眠/疲劳（ρ=-0.299，p=0.005）和杂项领域（ρ=-0.318，p=0.003）之间存在中度负相关。
在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 与运动评分之间的明确关系。需要进行大规模的前瞻性研究，以评估和确定这些关联。
