Institute for Veterinary-Pathology, Justus-Liebig-University Giessen, Giessen, Germany.
Department of Veterinary Clinical Sciences, Small Animal Clinic, Neurosurgery, Neuroradiology and Clinical Neurology, Justus-Liebig-University Giessen, Giessen, Germany.
J Vet Intern Med. 2020 Jul;34(4):1570-1575. doi: 10.1111/jvim.15803. Epub 2020 May 23.
Periventricular nodular heterotopia is a common neuronal malformation in humans, often leading to epilepsy and other neurologic diseases. A 2-month-old female Chihuahua weighing 750 g was examined because of a history of epileptic seizures and abnormalities in gait and behavior. Results of the clinical examination were consistent with a multifocal neurologic disease with localization in the forebrain and spinovestibular system. The magnetic resonance imaging showed multiple bilateral periventricular nodules isointense to gray matter and ventriculomegaly. Histopathological and immunohistological examination of the brain revealed that periventricular nodules consisted of neurons, fewer astrocytes, and some oligodendroglia consistent with periventricular nodular heterotopias.
室周结节性异位是一种常见的人类神经元畸形，常导致癫痫和其他神经疾病。一只 2 个月大、体重 750 克的雌性吉娃娃因癫痫发作和步态及行为异常而接受检查。临床检查结果与前脑和脊髓前庭系统多灶性神经疾病一致。磁共振成像显示双侧室周多发结节与灰质等信号，脑室扩大。脑的组织病理学和免疫组织化学检查显示，室周结节由神经元、较少的星形胶质细胞和一些少突胶质细胞组成，符合室周结节性异位。
