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[医院在乙肝主动免疫预防方面的经验]

[Hospital experience in active immunoprophylaxis against HBV].

作者信息

Guasti E, Cavagna G, Giaquinto C, Temporin G F

机构信息

Divisione Pediatrica O.C. di Rovigo.

出版信息

Pediatr Med Chir. 1988 Nov-Dec;10(6):571-3.

PMID:3244536
Abstract

According to the Ministry of Health, at the paediatric section of Central Hospital of Rovigo, a vaccination campaign against HBV was undertaken in the year 1985 with the main purpose to reduce the sickness-rate and the mortality by HBV. Two vaccination patterns have been applied and they show to be efficient. 46 risk-subjects divided into two groups were vaccinated: group A: newborn, sons of women HBc Ag positive; group B: children living together with carriers or subjects sick of hepatitis B. The group A subjects had undergone to passive immunoprophylaxis at birth and to a vaccination cycle. The group B subjects only vaccination. The research of antibody titres produced by the vaccination demonstrated in the majority of cases greater than 121 IU/L. Only about 25% of vaccinated subjects showed a feeble movement of transaminases. The children's parents have cooperated very well.

摘要

据卫生部称,在罗维戈中心医院儿科,1985年开展了一场针对乙肝病毒(HBV)的疫苗接种运动,主要目的是降低HBV的发病率和死亡率。采用了两种疫苗接种模式,且都显示出有效。46名风险对象被分为两组进行接种:A组:新生儿,母亲乙肝核心抗原(HBc Ag)呈阳性的子女;B组:与乙肝携带者或乙肝患者共同生活的儿童。A组对象在出生时接受了被动免疫预防并完成了一个疫苗接种周期。B组对象仅进行了疫苗接种。对接种产生的抗体滴度研究表明,大多数情况下抗体滴度大于121国际单位/升(IU/L)。只有约25%的接种对象转氨酶有轻微波动。儿童家长配合得非常好。

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