剖宫产术中口服阿奇霉素对婴儿鼻咽部获得性大环内酯类耐药组的影响：一项随机对照试验。
Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial.
机构信息
Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
出版信息
Clin Infect Dis. 2020 Dec 15;71(12):3222-3225. doi: 10.1093/cid/ciaa609.
Abstract
UNLABELLED
In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx.
CLINICAL TRIALS REGISTRATION
NCT1800942.
摘要
未加标签
在一项产时阿奇霉素随机临床试验的样本的事后分析中，我们发现，母亲接受该药物治疗的儿童在 28 天时，而非 12 个月时，其大环内酯类耐药基因 msr(A)和 ermC 的流行率更高。这 2 个基因在鼻咽部呈正相关。
临床试验注册
NCT1800942。
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