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学龄前儿童在长期大规模阿奇霉素分发后的肠道抗药性组：一项集群随机试验。

Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.

机构信息

The Carter Center, Niamey, Niger.

Ministry of Health, Niamey, Niger.

出版信息

Clin Infect Dis. 2021 Oct 5;73(7):1292-1295. doi: 10.1093/cid/ciab485.

DOI:10.1093/cid/ciab485
PMID:34037753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8492121/
Abstract

UNLABELLED

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.

CLINICAL TRIALS REGISTRATION

NCT02047981.

摘要

未加标签

我们评估了接受 10 次双年度阿奇霉素分配治疗的社区儿童的肠道耐药组。虽然大环内酯类耐药性在阿奇霉素组仍然较高，但在早期观察到的非大环内酯类耐药性的选择并没有持续。纵向耐药监测应该是大规模分发计划的一个关键组成部分。

临床试验注册

NCT02047981。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f7/8492121/5d6b2cc7953d/ciab485f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f7/8492121/5d6b2cc7953d/ciab485f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f7/8492121/5d6b2cc7953d/ciab485f0001.jpg

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本文引用的文献

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Travel-Related Antimicrobial Resistance: A Systematic Review.与旅行相关的抗菌药物耐药性：一项系统综述。
Trop Med Infect Dis. 2021 Jan 16;6(1):11. doi: 10.3390/tropicalmed6010011.
2
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N Engl J Med. 2020 Nov 12;383(20):1941-1950. doi: 10.1056/NEJMoa2002606.
3
The role of "spillover" in antibiotic resistance.“溢出”在抗生素耐药性中的作用。
阿奇霉素在尼日尔农村低体重婴儿中的质量分布与儿童死亡率：AVENIR整群随机试验的亚组分析
BMJ Open. 2025 Mar 27;15(3):e097916. doi: 10.1136/bmjopen-2024-097916.
4
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease.博茨瓦纳儿童在阿奇霉素治疗急性严重腹泻病后对耐药组影响较小。
J Infect Dis. 2024 Jul 25;230(1):239-249. doi: 10.1093/infdis/jiae049.
5
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