Liu B, Burbach J P
Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.
Peptides. 1988 Sep-Oct;9(5):973-8. doi: 10.1016/0196-9781(88)90075-7.
Vasopressin levels and vasopressin-converting aminopeptidase activity were measured in the rat pineal gland during the 24 hr light-dark cycle. A rhythmic variation in peptide levels and peptidase activity occurred. At the onset of light at 6.00 hr, the peptidase displayed a significant, short-lasting (approximately 3 hr) increase of about 35% in activity, while a decrease of 28% in pineal vasopressin levels was observed. The changes in peptidase activity and peptide level were not triggered by light per se, since they persisted to occur at the same time point in animals which were not exposed to light, indicating the circadian nature of the rhythmicity. These changes were specific to the pineal gland, since other tissues, like hippocampus and pituitary gland, did not show these daily variations. The data suggest a relationship between vasopressin levels and vasopressin-converting aminopeptidase activity.
在24小时明暗周期内，对大鼠松果体中的加压素水平和加压素转化氨肽酶活性进行了测量。肽水平和肽酶活性出现了节律性变化。在6.00小时光照开始时，肽酶活性显著短暂（约3小时）增加约35%，而松果体加压素水平则下降了28%。肽酶活性和肽水平的变化并非由光本身触发，因为在未暴露于光的动物中，它们仍在同一时间点出现，表明这种节律具有昼夜节律性。这些变化是松果体特有的，因为其他组织，如海马体和垂体，并未显示出这些每日变化。数据表明加压素水平与加压素转化氨肽酶活性之间存在关联。
