College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, China; Department of Neurology, Shimane University Faculty of Medicine, Izumo, 6938501, Japan.
School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
Exp Parasitol. 2020 Aug;215:107917. doi: 10.1016/j.exppara.2020.107917. Epub 2020 May 22.
Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus infection.
包虫病（CE）是一种由细粒棘球绦虫引起的全球性危险的人畜共患寄生虫病。CE 的发展涉及复杂的免疫机制，包括多种免疫细胞和效应分子的参与。髓系来源的抑制细胞（MDSCs）被认为参与慢性和急性炎症性疾病。在本研究中，我们旨在描述 CE 中 MDSCs 的免疫功能，以提高对 CE 的认识、预防和治疗。我们的结果表明，在棘球蚴感染过程中，过表达 Ly6C 和 Ly6G 的 MDSCs 以依赖 NO 的方式抑制 T 辅助 2 细胞的形成和活性。
