Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
Neurosci Lett. 2020 Aug 10;733:135073. doi: 10.1016/j.neulet.2020.135073. Epub 2020 May 22.
Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of a 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While such light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation in vivo.
褪黑素是一种重要的松果腺激素，调节人类和动物的昼夜节律和睡眠。越来越多的临床和啮齿动物证据表明，褪黑素还调节情感行为和认知。斑马鱼（Danio rerio）在转化神经科学研究中迅速成为一种强大的新型模式生物。在这里，我们评估了 24 小时褪黑素处理对昼夜节律紊乱的成年斑马鱼行为和生理的影响，这种光照暴露会引起斑马鱼明显的认知和神经内分泌（皮质醇）缺陷，但 24 小时褪黑素处理可逆转这些影响。总的来说，这些发现表明褪黑素对斑马鱼的情感和认知表型有积极的调节作用，并加强了斑马鱼模型在研究昼夜节律、认知和行为过程及其体内神经内分泌调节方面的应用。
