Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.
Neurosci Biobehav Rev. 2019 Apr;99:117-127. doi: 10.1016/j.neubiorev.2018.12.025. Epub 2019 Jan 3.
Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.
褪黑素是一种重要的激素，调节昼夜节律、神经保护和神经免疫过程。然而，其在大脑机制中的确切生理作用仍知之甚少。在这里，我们根据体内临床和实验研究，总结了褪黑素与脑部疾病和行为之间的关联。除了啮齿动物模型外，斑马鱼（Danio rerio）也越来越多地被应用于生物医学和神经科学研究中。在这里，我们讨论了斑马鱼的褪黑素神经生物学，并将这些发现与临床和啮齿动物数据进行了比较。我们还讨论了褪黑素在斑马鱼中的基因组效应，并强调了斑马鱼模型在研究褪黑素神经生物学和药物发现方面的日益重要性。
