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SARS-CoV-2 与糖尿病:疾病的新挑战。

SARS-CoV-2 and diabetes: New challenges for the disease.

机构信息

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Faculdade de Farmácia, University of Porto, Porto, Portugal.

出版信息

Diabetes Res Clin Pract. 2020 Jun;164:108228. doi: 10.1016/j.diabres.2020.108228. Epub 2020 May 22.

Abstract

A novel small enveloped RNA virus with the typical characteristic of the family to which it belongs, a crown, hence the name coronavirus, appeared in December 2019 in Wuhan, China, and subdued the world to its influence. The particular severity of the disease and higher mortality rates in patients with associated morbidities, including hypertension, obesity and diabetes, increases the concern over the consequences of this pandemic. In this review, the features of SARS-CoV-2 will be addressed, as well as the reasons why it poses a particular challenge to diabetic patients. We will also highlight the recent treatment strategies being explored to control this pandemic. Emerging evidence demonstrates that the correct management of diabetes in those patients infected with SARS-CoV-2 is of utmost importance for the viral disease progression, therefore, the importance of blood glucose control will also be addressed.

摘要

一种新型的小包膜 RNA 病毒,具有其所属家族的典型特征,即冠状结构,因此被命名为冠状病毒,于 2019 年 12 月在中国武汉出现,并使全球受到其影响。该疾病的特殊严重性以及伴有高血压、肥胖症和糖尿病等合并症的患者的死亡率较高,增加了人们对这种大流行后果的担忧。在这篇综述中,将介绍 SARS-CoV-2 的特征,以及为什么它对糖尿病患者构成特殊挑战。我们还将重点介绍最近正在探索的控制这种大流行的治疗策略。新出现的证据表明,对于感染 SARS-CoV-2 的患者,正确的糖尿病管理对于病毒疾病的进展至关重要,因此,血糖控制的重要性也将得到解决。

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