West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Sci Total Environ. 2020 Sep 1;733:139114. doi: 10.1016/j.scitotenv.2020.139114. Epub 2020 May 1.
The evidence for adverse effects of ambient particulate matter (PM) pollution on mental disorders (MDs) is limited, especially in developing countries. This study aimed to quantify both PM related health impacts and corresponding economic loses for overall and specific MDs in southwestern China. Data regarding 134,292 hospital admissions for MDs were collected from local Compulsory Medical Insurance Database in 2013-2017. A generalized additive model (GAM) was applied to estimate the exposure-response effects of PM pollution on hospital admissions for MDs. And the cost of illness method (COI) was adopted to further assess corresponding hospitalization costs and productivity loses. It was showed that PM pollution was significantly related to hospital admissions for overall and specific MDs. Each 10 μg/m increase in concentrations of PM (particles with an aerodynamic diameters ≤10 μm), PM (≤ 2.5 μm) and PMc (2.5 μm < c < 10 μm) at the cumulative lag03 day would be responsible for 3.25% (95%CI: 2.34-4.16%), 6.38% (95%CI: 4.79-7.97%), and 3.81% (95%CI: 2.13-5.50%) increments in daily hospital admissions for MDs, respectively. Stronger associations were observed in males, cool season and people over 45 years. During the study period, PM pollution brought 1453.18 million Yuan economic losses for overall MDs, accounting for 0.026% of local GDP. This study suggested that short-term exposure to PM pollution, especially to PM, was associated with increased hospital admissions for MDs in southwestern China. In addition, potential benefits of lowering PM concentrations are considerable.
大气颗粒物（PM）污染对精神障碍（MD）的不良影响的证据有限，尤其是在发展中国家。本研究旨在量化西南地区 PM 相关健康影响和特定 MD 的相应经济损失。2013-2017 年，从当地医疗保险数据库中收集了 134292 例 MD 住院数据。应用广义加性模型（GAM）来估计 PM 污染对 MD 住院的暴露-反应关系。采用疾病成本法（COI）进一步评估相应的住院费用和生产力损失。结果表明，PM 污染与 MD 总住院率和特定 MD 住院率显著相关。PM（空气动力学直径≤10μm 的颗粒物）、PM（≤2.5μm）和 PMc（2.5μm<c<10μm）浓度每增加 10μg/m3，在累积滞后 0-3 天内，MD 的日住院率将分别增加 3.25%（95%CI：2.34-4.16%）、6.38%（95%CI：4.79-7.97%）和 3.81%（95%CI：2.13-5.50%）。在男性、凉爽季节和 45 岁以上人群中观察到更强的关联。在研究期间，PM 污染给 MD 带来了 1.45318 亿元的经济损失，占当地 GDP 的 0.026%。本研究表明，短期暴露于 PM 污染，尤其是 PM，与中国西南地区 MD 住院率的增加有关。此外，降低 PM 浓度的潜在效益是相当可观的。
