Hashimoto-Kitsukawa S, Okuyama S, Aihara H
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Pharmacol Biochem Behav. 1988 Oct;31(2):411-6. doi: 10.1016/0091-3057(88)90367-x.
We studied the effects of taurine on the caudate spindle in rats and compared the findings with those of gamma-aminobutyric acid (GABA) when these compounds were microinjected into the bilateral striatum. Three micrograms of taurine was without effect, whereas 10 and 30 micrograms of taurine enhanced the spindle in a dose-dependent manner. GABA (3-100 micrograms) had no significant effect. Apomorphine (0.5 mg/kg) and methamphetamine (0.5 mg/kg) given intravenously to pargyline-pretreated rats suppressed the spindle. The suppressing effects of these drugs were reduced by taurine (3 micrograms) at the dose which, per se, did not affect the spindle. These results suggest that taurine may decrease the activity of striatal dopaminergic neurons and enhance the caudate spindle.
我们研究了牛磺酸对大鼠尾状核纺锤波的影响，并将这些化合物微量注射到双侧纹状体时的研究结果与γ-氨基丁酸（GABA）的结果进行了比较。3微克牛磺酸没有效果，而10微克和30微克牛磺酸以剂量依赖的方式增强了纺锤波。GABA（3 - 100微克）没有显著影响。给帕吉林预处理的大鼠静脉注射阿扑吗啡（0.5毫克/千克）和甲基苯丙胺（0.5毫克/千克）可抑制纺锤波。这些药物的抑制作用被牛磺酸（3微克）减弱，而该剂量本身并不影响纺锤波。这些结果表明，牛磺酸可能会降低纹状体多巴胺能神经元的活性并增强尾状核纺锤波。
