Kontro P, Oja S S
Department of Biomedical Sciences, University of Tampere, Finland.
Neuroscience. 1988 Jan;24(1):49-58. doi: 10.1016/0306-4522(88)90310-7.
The spontaneous and potassium-stimulated release of preloaded taurine and GABA from striatal slices of adult and 7-day-old rats were studied using a superfusion system. Particular attention was paid to mutual interactions of taurine and GABA with dopamine in the release processes. Potassium stimulation (50 mM) enhanced taurine release more in the immature than in the adult striatum, whereas the response was the opposite with GABA release. Spontaneous taurine efflux was increased by dopamine and apomorphine, whereas stimulated release was suppressed by these agents in both age groups. This dopamine effect was partially antagonized by haloperidol, suggesting that dopaminergic systems were able to modify taurine release, possibly via dopaminergic receptors. Dopamine and apomorphine had similar but more inconsistent effects on striatal GABA release, which were not, however, mediated through conventional dopamine receptors. Stimulation with 25 mM K+ caused an 11-fold increase in striatal dopamine release: this effect was potentiated by taurine, while the actions of GABA on dopamine release were variable.
利用灌流系统研究了成年大鼠和7日龄大鼠纹状体切片中预先加载的牛磺酸和γ-氨基丁酸（GABA）的自发释放及钾刺激释放情况。特别关注了牛磺酸和GABA在释放过程中与多巴胺的相互作用。钾刺激（50 mM）使未成熟纹状体中牛磺酸的释放增强程度大于成年纹状体，而GABA释放的反应则相反。多巴胺和阿扑吗啡增加了牛磺酸的自发流出，而在两个年龄组中，这些药物均抑制了刺激释放。氟哌啶醇部分拮抗了这种多巴胺效应，表明多巴胺能系统可能通过多巴胺能受体调节牛磺酸的释放。多巴胺和阿扑吗啡对纹状体GABA释放有相似但更不一致的影响，然而，这些影响并非通过传统多巴胺受体介导。用25 mM K⁺刺激导致纹状体多巴胺释放增加11倍：牛磺酸增强了这种效应，而GABA对多巴胺释放的作用则各不相同。
