Okuyama S, Hashimoto S, Aihara H
Neurosci Lett. 1985 Aug 16;59(1):27-32. doi: 10.1016/0304-3940(85)90210-1.
We examined the caudate spindle in control and pargyline-pretreated rats following bilateral application of 3 doses (15, 50 and 150 micrograms/site) of dopamine (DA) into the caudate nucleus. The highest dose of DA (150 micrograms) suppressed the spindle, whereas lower doses (15, 50 micrograms) enhanced the spindle in control rats. Haloperidol given into the bilateral caudate nucleus increased the spindle in control rats. In pargyline-pretreated rats, 50 and 150 micrograms DA caused marked suppression, but 15 micrograms DA caused enhancement. These findings indicate that the DA system may mediate the development of the caudate spindle. Suppression of the caudate spindle induced by intracaudate DA injection may be due to stimulation of postsynaptic DA receptors and enhancement mediated by DA autoreceptors on the DA nerve terminals in the caudate nucleus with a subsequent inhibition of DA neurotransmission.
我们在向对照组和帕吉林预处理的大鼠双侧尾状核注射3种剂量（15、50和150微克/部位）多巴胺（DA）后，对尾状核纺锤波进行了检测。最高剂量的DA（150微克）抑制了纺锤波，而较低剂量（15、50微克）在对照组大鼠中增强了纺锤波。向双侧尾状核注射氟哌啶醇增加了对照组大鼠的纺锤波。在帕吉林预处理的大鼠中，50和150微克DA引起明显抑制，但15微克DA引起增强。这些发现表明DA系统可能介导尾状核纺锤波的产生。尾状核内注射DA诱导的尾状核纺锤波抑制可能是由于刺激了突触后DA受体，以及由尾状核DA神经末梢上的DA自身受体介导的增强作用，随后抑制了DA神经传递。
