Coordinación de Investigación en Salud, CMN "Siglo XXI", IMSS. Av. Cuauhtemoc 330, Delegación Cuauhtémoc, Mexico City, 06720, Mexico; Servicio de Hematología Pediátrica, Hospital General "Gaudencio González Garza", CMN "La Raza", IMSS. Calzada Vallejo y Jacarandas S/N Col. La Raza, Delegación Azcapotzalco, Mexico City, 02990, Mexico.
Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de AltaEspecialidad (UMAE) Hospital de Pediatría, Centro Médico Nacional (CMN) "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS). Av. Cuauhtemoc 330, Delegación Cuauhtémoc, Mexico City, 06720, Mexico.
Cancer Epidemiol. 2020 Aug;67:101731. doi: 10.1016/j.canep.2020.101731. Epub 2020 May 19.
The parental age at conception has been reported to be a risk factor for childhood acute leukaemia (AL); however, the relationship is controversial. The aim of the present study was to investigate the association between parental age at conception and the risk of AL in Mexican children, a population with a high incidence of the disease and a high prevalence of pregnancies in adolescents and young adults.
A multicentre case-control study was conducted. Incident AL cases younger than 17 years of age diagnosed between 2010 and 2015 were included. Controls were matched with cases according to age, sex, and health institution. Using logistic regression analysis, adjusted odds ratios (aOR) and 95 % confidence intervals (95 % CI) were calculated for each maternal stratum after adjusting for paternal age at conception of index child. The maternal age between 25 and 29.99 years was selected as the reference category.
In most strata where maternal and paternal ages were assessed, no association was found with the risk of developing acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring. An increased risk for AML was observed when the mother was between 20 and 24.99 years of age and the father aged 25-29.99 years (aOR, 1.94; 95 % CI, 1.03-3.67). In addition, there was a positive association for ALL when the mother´s age was between 20 and 24.99 years and the father was <20 years of age, however, a very wide confidence interval was noted (aOR, 12.26; 95 % CI, 1.41-106.83).
In the present study, maternal and paternal ages assessed in different strata showed little association with risk of developing ALL and AML in children. Positive associations between risk of both types of childhood AL were observed with younger paternal and maternal ages.
据报道，父母受孕时的年龄是儿童急性白血病（AL）的一个危险因素；然而，这种关系存在争议。本研究的目的是调查父母受孕时的年龄与墨西哥儿童 AL 发病风险之间的关系，墨西哥是该病发病率较高且青少年和年轻成年人妊娠率较高的人群。
进行了一项多中心病例对照研究。纳入了 2010 年至 2015 年间诊断为 17 岁以下的新发 AL 病例。对照与病例按年龄、性别和医疗机构相匹配。使用逻辑回归分析，在调整了子女父亲的受孕年龄后，对每个母亲年龄层进行调整优势比（aOR）和 95%置信区间（95%CI）计算。将母亲年龄在 25-29.99 岁的人群选为参考类别。
在大多数评估母亲和父亲年龄的年龄层中，未发现与子女患急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）的风险相关。当母亲年龄在 20-24.99 岁而父亲年龄在 25-29.99 岁时，AML 的风险增加（aOR，1.94；95%CI，1.03-3.67）。此外，当母亲年龄在 20-24.99 岁而父亲年龄<20 岁时，ALL 与风险呈正相关，但置信区间很宽（aOR，12.26；95%CI，1.41-106.83）。
在本研究中，不同年龄层评估的母亲和父亲年龄与儿童 ALL 和 AML 发病风险的相关性不大。两种类型的儿童 AL 的风险与父母的年轻年龄呈正相关。
