硝苯地平对清醒神经源性高血压大鼠血压和心率的影响。

Effects of nifedipine on blood pressure and heart rate in conscious neurogenic hypertensive rats.

作者信息

Vasquez E C, Cabral A M, Mill J G, Moyses M R

机构信息

Departemento Ciencias Fisiologicas, Universidade Federal do Espirito Santo, Vitoria, Brasil.

出版信息

Pharmacology. 1988;37(6):370-5. doi: 10.1159/000138491.

DOI:10.1159/000138491

PMID:3244743

Abstract

The effects of nifedipine (15 micrograms/kg, i.v.) on mean blood pressure (MBP) and heart rate were studied in neurogenic hypertensive rats (NHR), compared with renovascular hypertensive (RHR), and control (CR) rats. The maximal MBP reduction reached 32, 37 and 9%, respectively. The baseline MBP was recovered after 120, 150, and 5 min, respectively. The hypotension was not accompanied by changes in the baseline high heart rate of NHR and by tachycardia in CR and RHR groups. The data show the antihypertensive efficacy of nifedipine in both models of hypertension and indicate that under conditions of increased sympathetic tone the cardiac pacemaker cannot be easily inhibited by nifedipine.

摘要

在神经源性高血压大鼠（NHR）中研究了硝苯地平（15微克/千克，静脉注射）对平均血压（MBP）和心率的影响，并与肾血管性高血压大鼠（RHR）及对照大鼠（CR）进行了比较。MBP的最大降幅分别达到32%、37%和9%。基线MBP分别在120分钟、150分钟和5分钟后恢复。低血压并未伴随NHR基线高心率的变化，也未在CR和RHR组中引发心动过速。数据表明硝苯地平在两种高血压模型中均具有降压效果，并表明在交感神经张力增加的情况下，硝苯地平不易抑制心脏起搏器。