Martins Cavaco Ana C, Dâmaso Sara, Casimiro Sandra, Costa Luís
Luis Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028, Lisboa, Portugal.
Serviço de Oncologia, Hospital de Santa Maria-CHULN, 1649-028, Lisboa, Portugal.
Cancer Metastasis Rev. 2020 Sep;39(3):603-623. doi: 10.1007/s10555-020-09888-5.
Progression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Desmoplasia and collagen biomarkers have been associated with relapse and death in cancer patients. Despite the increasing interest in ECM and in the desmoplastic process in tumor microenvironment as prognostic factors and therapeutic targets in cancer, further research is required for a better understanding of these aspects of cancer biology. In this review, published evidence correlating collagen with cancer prognosis is retrieved and analyzed, and the role of collagen and its fragments in cancer pathophysiology is discussed.
癌细胞扩散至肿瘤周围组织并发生转移是癌症的一个标志，这一过程需要持续的细胞间相互作用和组织重塑。事实上，转移可被视为一种由癌细胞精心策划的组织疾病，会导致新器官的肿瘤性定植。胶原蛋白是细胞外基质（ECM）的主要成分，越来越多的证据表明它在癌症进展和转移中起着重要作用。促结缔组织增生和胶原蛋白生物标志物与癌症患者的复发和死亡有关。尽管人们对细胞外基质以及肿瘤微环境中的促结缔组织增生过程作为癌症的预后因素和治疗靶点越来越感兴趣，但仍需要进一步研究以更好地理解癌症生物学的这些方面。在本综述中，检索并分析了将胶原蛋白与癌症预后相关联的已发表证据，并讨论了胶原蛋白及其片段在癌症病理生理学中的作用。
