Murdoch Children's Research Institute, Parkville, Australia.
The Royal Children's Hospital, Parkville, Australia.
Pediatr Nephrol. 2020 Oct;35(10):1959-1966. doi: 10.1007/s00467-020-04612-5. Epub 2020 May 23.
Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC.
The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs.
A total of 378 samples with equal numbers of males and females were analysed for serum CysC. No outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots.
This study established continuous paediatric reference intervals (RIs) for serum CysC in healthy term neonates and children. The continuous RIs generated from this study show age-based dynamic changes as well as blood group and gender-specific differences for serum CysC. Graphical abstract.
血清胱抑素 C（CysC）是一种很有前途的肾功能生物标志物，与肌酐相比，其准确性和灵敏度更高。为了在临床实践中更好地利用血清 CysC，本研究旨在建立连续的儿科血清 CysC 参考区间（RI）。
研究对象为健康足月新生儿和 30 天至 18 岁的儿童。采集静脉血样，采用免疫比浊法测量血清 CysC 水平。应用分数多项式回归模型和分位数回归对数据进行统计分析，以生成连续的 RI。
对 378 份性别比例相等的血清 CysC 样本进行了分析，未发现离群值。连续 RI 以方程和图形散点图的形式呈现。
本研究建立了健康足月新生儿和儿童的血清 CysC 连续儿科参考区间（RI）。本研究得出的连续 RI 显示了基于年龄的动态变化以及血清 CysC 的血型和性别特异性差异。
