ProPath Dermatopathology, Dallas, Texas, USA.
Univeristy of Texas Southwestern Medical Center, Department of Dermatology, Dallas, Texas, USA.
J Cutan Pathol. 2020 Oct;47(10):967-969. doi: 10.1111/cup.13759. Epub 2020 Jun 8.
Structures resembling Meissner corpuscles have been described in various nerve sheath tumors, including schwannomas and neurofibromas. When present, they are focal or scattered, and rarely a prominent feature of the lesion. Here, we report a case of a 39-year-old female who presented with an isolated lesion on her abdomen. Histopathologically, the tumor was almost exclusively composed of Meissner corpuscle-like structures (pseudo-meissnerian bodies). At a small edge of the tumor, there were features of a classic neurofibroma, with a mixture of Schwann cells, fibroblast-like cells, and interspersed mast cells. We propose the term "meissnerian neurofibroma" for this extremely rare variant of neurofibroma.
在各种神经鞘瘤中,包括神经鞘瘤和神经纤维瘤,已经描述了类似于迈斯纳小体的结构。当存在时,它们是局灶性或散在性的,很少是病变的显著特征。在这里,我们报告了一例 39 岁女性的病例,她的腹部出现孤立性病变。组织病理学上,肿瘤几乎完全由迈斯纳小体样结构(假迈斯纳小体)组成。在肿瘤的一小部分边缘,存在典型神经纤维瘤的特征,有 Schwann 细胞、成纤维样细胞和散在的肥大细胞混合存在。我们提出“迈斯纳神经纤维瘤”这一术语来描述这种非常罕见的神经纤维瘤变体。