白细胞介素 17 家族细胞因子与银屑病
Cytokines of the IL-17 family in psoriasis.
机构信息
Department of Dermatology and Allergy Biederstein, University hospital of the Technical University Munich (TUM), Munich, Germany.
Division of Dermatology and Venereology and Department of Pathology and Immunology, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
出版信息
J Dtsch Dermatol Ges. 2020 Jul;18(7):675-681. doi: 10.1111/ddg.14124. Epub 2020 May 24.
Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.
各种免疫细胞及其信使物质影响银屑病的发展。白细胞介素-17（IL-17）家族的细胞因子尤为重要。除了在银屑病发病机制中起核心作用的白细胞介素-17A（IL-17A）外，IL-17 家族的其他亚型也具有促炎作用。本文就 6 种白细胞介素-17 亚型（尤其是它们的生理和病理特性及其对银屑病治疗的意义），综述了银屑病的免疫发病机制的最新研究进展。
Zotero 插件