Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
J Clin Lab Anal. 2022 Sep;36(9):e24643. doi: 10.1002/jcla.24643. Epub 2022 Aug 9.
Proinflammatory cytokines mediate anxiety and depression in various ways, such as immunity, inflammation, and the hypothalamic-pituitary-adrenal axis. This study intended to further explore the linkage of common proinflammatory cytokine levels with anxiety and depression in psoriasis patients.
Totally, 150 psoriasis patients and 50 healthy controls (HCs) were included; the serum samples were collected, then common proinflammatory cytokines were measured by ELISA. Hospital Anxiety and Depression Scale (HADS) was assessed.
HADS-anxiety (HADS-A) score, HADS-depression (HADS-D) score, TNF-α, IL-1β, IL-6, IL-12, IL-17A, and IL-23 were all increased in psoriasis patients compared to HCs (all p < 0.05). In psoriasis patients, TNF-α (p = 0.001), IL-12 (p = 0.035), and IL-17A (p < 0.001), but not IL-1β (p = 0.255), IL-6 (p = 0.248), and IL-23 (p = 0.216), were positively linked to HADS-A score. Meanwhile, TNF-α (p = 0.007) and IL-17A (p = 0.007) were enhanced in psoriasis patients with anxiety in contrast to those without anxiety; whereas IL-1β (p = 0.178), IL-6 (p = 0.360), IL-12 (p = 0.239), and IL-23 (p = 0.450) were not different. TNF-α (p < 0.001), IL-1β (p = 0.013), Il-17A (p < 0.001), and IL-23 (p = 0.023), but not IL-6 (p = 0.143) and IL-12 (p = 0.158), were positively linked to HADS-D score. Concurrently, TNF-α (p = 0.015), IL-17A (p < 0.001), and IL-23 (p = 0.017) were climbed in psoriasis patients with depression by comparison to those without depression; whereas IL-1β (p = 0.113), IL-6 (p = 0.237), IL-12 (p = 0.660) did not differ.
TNF-α, IL-17A, and IL-23 increments reflect anabatic anxiety and depression in psoriasis patients, uncovering the potency of proinflammatory cytokines measurement for monitoring or even preventing psoriasis patients' anxiety and depression.
促炎细胞因子通过免疫、炎症和下丘脑-垂体-肾上腺轴等多种途径介导焦虑和抑郁。本研究旨在进一步探讨常见促炎细胞因子水平与银屑病患者焦虑和抑郁之间的联系。
共纳入 150 例银屑病患者和 50 例健康对照者（HCs）；采集血清样本，采用 ELISA 法检测常见促炎细胞因子。采用医院焦虑抑郁量表（HADS）进行评估。
与 HCs 相比，银屑病患者的 HADS 焦虑（HADS-A）评分、HADS 抑郁（HADS-D）评分、TNF-α、IL-1β、IL-6、IL-12、IL-17A 和 IL-23 均升高（均 P<0.05）。在银屑病患者中，TNF-α（P=0.001）、IL-12（P=0.035）和 IL-17A（P<0.001）与 HADS-A 评分呈正相关，而 IL-1β（P=0.255）、IL-6（P=0.248）和 IL-23（P=0.216）与 HADS-A 评分无相关性。同时，与无焦虑的银屑病患者相比，有焦虑的银屑病患者的 TNF-α（P=0.007）和 IL-17A（P=0.007）升高；而 IL-1β（P=0.178）、IL-6（P=0.360）、IL-12（P=0.239）和 IL-23（P=0.450）无差异。TNF-α（P<0.001）、IL-1β（P=0.013）、IL-17A（P<0.001）和 IL-23（P=0.023）与 HADS-D 评分呈正相关，而 IL-6（P=0.143）和 IL-12（P=0.158）与 HADS-D 评分无相关性。同时，与无抑郁的银屑病患者相比，有抑郁的银屑病患者的 TNF-α（P=0.015）、IL-17A（P<0.001）和 IL-23（P=0.017）升高；而 IL-1β（P=0.113）、IL-6（P=0.237）、IL-12（P=0.660）无差异。
TNF-α、IL-17A 和 IL-23 的增加反映了银屑病患者的焦虑和抑郁加重，提示检测促炎细胞因子水平有助于监测甚至预防银屑病患者的焦虑和抑郁。
