Analysis of Circulating Tumor Cells Lab, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, University Campus, Athens, Greece.
Analysis of Circulating Tumor Cells Lab, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, University Campus, Athens, Greece.
Adv Clin Chem. 2020;97:13-71. doi: 10.1016/bs.acc.2020.01.001. Epub 2020 Feb 14.
Ovarian cancer has the worst survival rate because it is typically diagnosed at advanced stage. Despite treatment, the disease commonly recurs due to chemo-resistance. Liquid biopsy, based on minimally invasive blood tests, has the advantage of following tumor evolution in real time, offering novel insights on cancer prevention and treatment. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating cell-free microRNAs (cfmiRNAs) and circulating exosomes represent the major components of liquid biopsy. In this chapter, we provide an overview of recent research on CTCs, ctDNA, cfmiRNAs and exosomes in ovarian cancer. We also focus on the clinical value of liquid biopsy in early diagnosis, prognosis, treatment response, as well as screening in the general population.
卵巢癌的存活率最差，因为它通常在晚期才被诊断出来。尽管经过治疗，由于化疗耐药，该疾病通常会复发。基于微创血液检测的液体活检具有实时跟踪肿瘤演变的优势，为癌症的预防和治疗提供了新的见解。循环肿瘤细胞（CTC）、循环肿瘤 DNA（ctDNA）、循环无细胞 microRNAs（cfmiRNAs）和循环外泌体是液体活检的主要组成部分。在本章中，我们概述了最近在卵巢癌中对 CTC、ctDNA、cfmiRNAs 和外泌体的研究。我们还重点介绍了液体活检在早期诊断、预后、治疗反应以及普通人群筛查中的临床价值。
