Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Laboratory of Biomedical Cell Technologies, Department of Medical Biology and Biotechnology, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Int Rev Neurobiol. 2020;151:299-324. doi: 10.1016/bs.irn.2020.03.010. Epub 2020 May 13.
Glioblastoma is one of the most aggressive human brain tumors. Even following all the modern protocols of complex treatment, the median patient survival typically does not exceed 15 months. This review analyzes the main reasons for glioblastoma resistance to therapy, as well as attempts at categorizing the main approaches to increasing chemotherapy efficiency. Special emphasis is placed on the specific group of compounds, known as marine alkaloids and their synthetic derivatives exerting a general antitumor effect on glioblastoma cells. The unique mechanisms of marine alkaloid influence on the tumor cells prompt considering them as a promising basis for creating new chemotherapeutic agents for glioblastoma treatment.
胶质母细胞瘤是最具侵袭性的人类脑肿瘤之一。即使采用了所有现代的综合治疗方案，患者的中位生存期通常也不超过 15 个月。本综述分析了胶质母细胞瘤对治疗产生耐药性的主要原因，以及提高化疗效率的主要方法的尝试。特别强调了一类特殊的化合物，即海洋生物碱及其合成衍生物，它们对胶质母细胞瘤细胞具有普遍的抗肿瘤作用。海洋生物碱对肿瘤细胞影响的独特机制促使人们将其视为开发治疗胶质母细胞瘤的新化疗药物的有前途的基础。
