来自天然产物库的SARS-CoV-2主要蛋白酶抑制剂作为治疗冠状病毒科感染的候选疗法
SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections.
作者信息
Khanfar Mohammad Abdalmoety, Saleh Mohammad Issa
机构信息
College of Pharmacy, Alfaisal University, Al Takhassusi Rd, Riyadh, 11533, Saudi Arabia.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, P.O Box 13140, Amman 11942, Jordan.
出版信息
Curr Med Chem. 2025;32(4):688-719. doi: 10.2174/0109298673271674231109052709.
BACKGROUND
The main protease (M) is a crucial enzyme for the life cycle of SARS-CoV-2 and a validated target for the treatment of COVID-19 infection. Natural products have been a proper alternative for treating viral diseases by modulating different steps of the life cycle of many viruses.
OBJECTIVE
This review article is designed to summarize the cumulative information of natural-derived M inhibitors that are validated by experimental biological testing.
METHODS
The natural-derived M inhibitors of SARS-CoV-2 that have been discovered since the emergence of the COVID-19 pandemic are reviewed in this article. Only natural products with experimental validation are reported in this article. Collected compounds are classified according to their chemical identity into flavonoids, phenolic acids, quinones, alkaloids, chromones, stilbenes, tannins, lignans, terpenes, and other polyphenolic and miscellaneous natural-derived M inhibitors.
CONCLUSION
These compounds could serve as scaffolds for further lead-structure optimization for desirable potency, a larger margin of safety, and better oral activity.
背景
主要蛋白酶（M）是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）生命周期中的关键酶，也是治疗新型冠状病毒肺炎（COVID-19）感染的有效靶点。天然产物通过调节多种病毒生命周期的不同步骤，已成为治疗病毒性疾病的合适替代品。
目的
本文旨在总结经实验生物学测试验证的天然来源的M抑制剂的累积信息。
方法
本文综述了自COVID-19大流行以来发现的天然来源的SARS-CoV-2 M抑制剂。本文仅报道了经过实验验证的天然产物。收集的化合物根据其化学特性分为黄酮类、酚酸类、醌类、生物碱类、色酮类、芪类、单宁类、木脂素类、萜类以及其他多酚类和杂项天然来源的M抑制剂。
结论
这些化合物可作为进一步优化先导结构的支架，以获得理想的效力、更大的安全边际和更好的口服活性。
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