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亚美尼亚儿童疫苗接种的及时性,2015-2016 年。

Timeliness of childhood vaccinations in Armenia, 2015-2016.

机构信息

Department of Epidemiology, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave NW 5(th) Floor, Washington, DC 20052, United States.

Department of Epidemiology, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave NW 5(th) Floor, Washington, DC 20052, United States.

出版信息

Vaccine. 2020 Jun 19;38(30):4671-4678. doi: 10.1016/j.vaccine.2020.05.032. Epub 2020 May 21.

Abstract

BACKGROUND

Successful control of vaccine preventable diseases not only requires high coverage but also requires that vaccines are administered in a timely manner. Prior studies have examined the timing of vaccinations in Armenia and found that although vaccination coverage is high, children are not receiving the vaccinations in a timely manner. This study aims to further elucidate the timing and associated factors of childhood vaccinations among children in Armenia in 2015-2016.

METHODS

Data from the Armenia Demographic and Health Survey (ADHS) from 2015 to 2016 were used to examine the timing of WHO-recommended vaccinations during the first year of life of all living children under three years of age, which included a vaccine against tuberculosis (BCG), three doses of a diphtheria, pertussis and tetanus vaccine (DTP), three doses of a polio vaccine (Pol) and a measles-containing vaccine (MCV). The Kaplan-Meier method was used to assess age-appropriate receipt of vaccinations. Cox proportional hazards models with a shared gamma frailty to account for clustered sampling were used to determine factorsassociatedwith timely vaccinations.

RESULTS

Vaccination coverage was high ranging from 80.6% for the third dose of DTP to 98.4% for BCG, yet the proportion of children with delayed vaccinations increased with each dose in a series, with 51.9% and 48.5% having a delayed receipt of the third doses of DTP and Pol respectively. Factors associated with delayed vaccinations included female gender, certain regions of residence, previously delayed vaccinations, poorer wealth index and lower educational level of mother. There were no differences in timing of vaccinations between clusters.

CONCLUSIONS

Although coverage was generally high, a high proportion of children under three in Armenia experienced delays in receiving the recommended vaccinations. Continued focus on adherence to the immunization schedule is necessary to ensure optimal coverage and protection for children in Armenia from vaccine preventable diseases.

摘要

背景

成功控制疫苗可预防疾病不仅需要高覆盖率,还需要及时接种疫苗。先前的研究已经检查了亚美尼亚的疫苗接种时间,发现尽管疫苗接种覆盖率很高,但儿童并没有及时接种疫苗。本研究旨在进一步阐明 2015-2016 年亚美尼亚儿童的疫苗接种时间及其相关因素。

方法

使用 2015 年至 2016 年亚美尼亚人口与健康调查(ADHS)的数据,检查了所有 3 岁以下活产儿童在第一年接受世界卫生组织推荐疫苗的时间,包括结核病疫苗(BCG)、3 剂白喉、百日咳和破伤风疫苗(DTP)、3 剂脊髓灰质炎疫苗(Pol)和麻疹疫苗(MCV)。使用 Kaplan-Meier 方法评估疫苗接种的年龄适宜性。使用具有共享伽马脆弱性的 Cox 比例风险模型来确定与及时接种疫苗相关的因素。

结果

疫苗接种覆盖率很高,从第三剂 DTP 的 80.6%到 BCG 的 98.4%,但随着系列中每剂疫苗的接种,延迟接种的儿童比例增加,第三剂 DTP 和 Pol 的延迟接种比例分别为 51.9%和 48.5%。与延迟接种相关的因素包括女性性别、居住的某些地区、先前的延迟接种、较差的财富指数和母亲较低的教育水平。集群之间的疫苗接种时间没有差异。

结论

尽管覆盖率总体较高,但亚美尼亚有相当一部分 3 岁以下儿童延迟接受推荐的疫苗接种。为确保亚美尼亚儿童从疫苗可预防疾病中获得最佳覆盖和保护,需要继续关注疫苗接种时间表的遵守情况。

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