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自身免疫性胃炎致脊髓亚急性联合变性

Subacute Combined Degeneration of the Spinal Cord Caused by Autoimmune Gastritis.

机构信息

Second Department of Internal Medicine, Osaka Medical College, Japan.

Division of Neurology, Forth Department of Internal Medicine, Osaka Medical College, Japan.

出版信息

Intern Med. 2020 Sep 1;59(17):2113-2116. doi: 10.2169/internalmedicine.4684-20. Epub 2020 May 23.

Abstract

A 68-year-old woman presented with a 2-year history of worsening unsteady gait. Her neurological examination revealed peripheral neuropathy with lower limb sensory dominance. T2-weighted imaging revealed a disorder of the posterior cervical cord. Blood test findings revealed vitamin B deficiency, and gastroscopy revealed typical findings of autoimmune gastritis. She received vitamin B supplementation, but some peripheral neuropathy symptoms persisted due to longstanding vitamin B deficiency. Asymptomatic patients should undergo gastroscopy to detect autoimmune gastritis, as chronic vitamin B deficiency causes irreversible peripheral neuropathy.

摘要

一位 68 岁女性因进行性加重的不稳步态就诊,病史 2 年。神经系统检查发现下肢感觉占优势的周围神经病。T2 加权成像显示颈髓后部紊乱。血液检查结果显示维生素 B 缺乏,胃镜检查显示自身免疫性胃炎的典型表现。她接受了维生素 B 补充治疗,但由于长期维生素 B 缺乏,一些周围神经病症状仍然存在。无症状患者应行胃镜检查以发现自身免疫性胃炎,因为慢性维生素 B 缺乏可导致不可逆的周围神经病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e24/7516309/5ab84b43d297/1349-7235-59-2113-g001.jpg

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