FRAX 评分和近期跌倒史预测社区居住的老年人群肌少症的发生率：一项前瞻性队列研究。
FRAX score and recent fall history predict the incidence for sarcopenia in community-dwelling older adults: a prospective cohort study.
机构信息
Department of Physical Therapist, Faculty of Rehabilitation, Kawasaki University of Medical Welfare, Matsushima 288, Kurashiki, Okayama, 701-0193, Japan.
School of Health Science, Faculty of Medicine, Tottori University, Nishicho 86, Yonago, Tottori, 683-8503, Japan.
出版信息
Osteoporos Int. 2020 Oct;31(10):1985-1994. doi: 10.1007/s00198-020-05447-4. Epub 2020 May 24.
UNLABELLED
We hypothesized that the baseline FRAX score and previous falls would predict the incidence of sarcopenia in community-dwelling older adults who received medical check-ups. The FRAX score (hazard ratio [HR] = 1.087, 95% CI 1.014-1.167) and previous falls (HR = 5.181, 95% CI 1.002-26.777) were determined to be independent risk factors for the incidence of sarcopenia.
PURPOSE
This prospective study was performed to elucidate the prevalence and incidence of sarcopenia in community-dwelling older adults who received medical check-ups, and to determine whether FRAX score and fall history predict the incidence of sarcopenia.
METHODS
Participants were recruited from a group of individuals who had registered for an annual town-sponsored medical check-up. Study inclusion criteria were aged older than 60 years, living independently, and ability to walk without assistance. Individuals who received nursing care were excluded from the study. A total of 426 residential participants were analyzed. Demographic information, fall history of the previous year, and FRAX score without bone mineral density were assessed. The assessment for sarcopenia was based on the recommendations of the Asian Working Group for Sarcopenia.
RESULTS
The final sample for the assessment of sarcopenia incidence comprised 258 participants. The mean follow-up time was 2.92 years. The rate of sarcopenia was 1.06 cases per 100 person-years at risk. The Cox multivariate logistic regression model in our analysis was adjusted for age, gender, muscle mass, and covariates and showed that the FRAX score (HR = 1.087, 95% CI 1.014-1.167) and recent history of falls (HR = 5.181, 95% CI 1.002-26.777) were independent risk factors for the incidence of sarcopenia.
CONCLUSION
FRAX and history of falling can be a simple screening tool to raise awareness of the prevention of osteoporosis and sarcopenia in clinical settings.
目的
本前瞻性研究旨在阐明接受体检的社区居住老年人中肌少症的患病率和发生率，并确定 FRAX 评分和跌倒史是否可预测肌少症的发生。
方法
参与者从参加年度城镇赞助体检的人群中招募。研究纳入标准为年龄大于 60 岁、独立生活且无需辅助行走。不包括接受护理的个体。共分析了 426 名居住参与者。评估了人口统计学信息、前一年的跌倒史和不包括骨密度的 FRAX 评分。肌少症的评估基于亚洲肌少症工作组的建议。
结果
最终纳入 258 名参与者进行肌少症发生率评估。平均随访时间为 2.92 年。肌少症的发生率为每 100 人年风险 1.06 例。我们分析中的 Cox 多变量逻辑回归模型调整了年龄、性别、肌肉量和协变量，结果表明 FRAX 评分（HR=1.087，95%CI 1.014-1.167）和近期跌倒史（HR=5.181，95%CI 1.002-26.777）是肌少症发生的独立危险因素。
结论
FRAX 和跌倒史可以作为一种简单的筛查工具，提高临床对预防骨质疏松症和肌少症的认识。
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