Postgraduate Program in Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
Dental School, Federal University of Santa Catarina, Florianópolis, Brazil.
J Oral Pathol Med. 2021 Jan;50(1):1-9. doi: 10.1111/jop.13041. Epub 2020 Jun 23.
Podoplanin (PDPN) is a glycoprotein associated with epithelial-mesenchymal transition, invasion, and metastasis in several types of malignancies, including oral and oropharyngeal squamous cell carcinoma (OSCC). The aim of this systematic review (SR) was to summarize and critically appraise the available evidence about the association between PDPN immunoexpression and clinicopathological features and its utility as a prognostic marker in OSCC.
Five electronic databases and three gray literature databases were searched for immunohistochemical studies, which were selected in a two-phase process.
From 721 records identified, 22 cohort and seven analytical cross-sectional studies were included. Few studies reported that PDPN expression was associated with poorer survival rates in OSCC: overall survival = 4/12, disease-free survival = 4/7, and cancer-specific survival = 2/4 studies. Positive associations were most frequently reported on lymph node involvement, higher histopathological grade, and advanced clinical stages.
Within limitations of this SR, PDPN may be associated with lymph node involvement, histopathological grade, and clinical stage of OSCC. Current evidence suggests that PDPN could be a useful prognostic marker for OSCC that needs further exploration.
Podoplanin（PDPN）是一种糖蛋白，与几种恶性肿瘤中的上皮-间充质转化、浸润和转移有关，包括口腔和口咽鳞状细胞癌（OSCC）。本系统评价（SR）的目的是总结和批判性评估关于 PDPN 免疫表达与临床病理特征之间的关联及其作为 OSCC 预后标志物的效用的现有证据。
在两个阶段的过程中，对 5 个电子数据库和 3 个灰色文献数据库进行了免疫组织化学研究的搜索。
从确定的 721 条记录中，纳入了 22 项队列研究和 7 项分析性横断面研究。少数研究报告 PDPN 表达与 OSCC 的生存率较差相关：总生存率=4/12，无病生存率=4/7，癌症特异性生存率=4/4 项研究。阳性关联最常报道于淋巴结受累、较高的组织病理学分级和较晚期的临床分期。
在本 SR 的局限性内，PDPN 可能与 OSCC 的淋巴结受累、组织病理学分级和临床分期相关。目前的证据表明，PDPN 可能是 OSCC 的一种有用的预后标志物，需要进一步探索。
