Department of Biomedical Sciences, University of Padova, Padova, Italy.
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Int J Food Sci Nutr. 2021 Feb;72(1):37-44. doi: 10.1080/09637486.2020.1769569. Epub 2020 May 24.
We recently showed that the treatment with Resveratrol (RES) contrasts the effects of ageing on the skeletal muscle (SKM), reduces the appearance of tubular aggregates (TAs), and improves the fatigue resistance. Since fatigue resistance depends on the SKM capillary network, and RES has been described to improve vascularisation, we analysed the SKM capillarization in naturally ageing C57BL/6J male mice, fed with 0.04% RES in the diet for 6 months, which showed a better fatigue resistance in a previous work. Our data show an inverse correlation between the number of capillaries per fibre (CAF) and TAs in both control and treated type IIB fibres, and an increase of CAF in ageing SKM upon RES-treatment. The present work suggests that capillarization is one of the determinants of the development of TAs and fatigue resistance, and that RES can be considered a good candidate to counteract capillary rarefaction in the SKM tissue.
我们最近表明，白藜芦醇（RES）的治疗可对抗骨骼肌（SKM）衰老的影响，减少管状聚集物（TAs）的出现，并提高抗疲劳能力。由于抗疲劳能力取决于 SKM 的毛细血管网络，并且 RES 已被描述为可改善血管生成，我们分析了自然衰老的 C57BL/6J 雄性小鼠的 SKM 毛细血管化，这些小鼠在饮食中摄入 0.04% 的 RES 长达 6 个月，在之前的研究中表现出更好的抗疲劳能力。我们的数据显示，在对照组和经处理的 IIB 型纤维中，每根纤维的毛细血管数（CAF）与 TAs 呈负相关，并且 RES 处理可增加衰老 SKM 中的 CAF。本研究表明，毛细血管化是 TAs 形成和抗疲劳能力的决定因素之一，并且 RES 可被视为对抗 SKM 组织毛细血管稀疏的良好候选药物。
