College of Chemistry & Environmental Science, No. 180 Wusi East Road, Hebei University, Baoding, 071000, China.
College of Chemistry & Environmental Science, No. 180 Wusi East Road, Hebei University, Baoding, 071000, China; Key Laboratory of Analytical Science and Technology of Hebei Province, No. 180 Wusi East Road, Baoding, 071000, China.
Ecotoxicol Environ Saf. 2020 Sep 1;200:110770. doi: 10.1016/j.ecoenv.2020.110770. Epub 2020 May 22.
Tetrabromobisphenol A (TBBPA) in water from Xiongan New Area was determined by gas chromatography-mass spectrometry (GC-MS), simultaneous with its risk assessment. The optimal extraction conditions, derivatization factors (such as derivation reagent amount, derivatization time and temperature), and dissolution solvent were determined by orthogonal experiment. These results indicated the optimum derivatization time and temperature were 70 °C and 30 min, respectively, whilst the amount of derivatization reagent (N,O-bis (trimethylsilyl) trifluoroacetamide) was 40 μL. The optimum extraction efficiency was obtained when using the mixture of hexane-dichloromethane (1:1, v:v) with salt concentration of 6 g/L. Using the sample of S9 as control, the recovery experiments were performed with three different spiked levels. The water samples of Baiyang Lake and Fuhe river were analyzed using the optimized conditions. Those results showed that the concentrations of TBBPA in samples ranged from 18.5 ng/L to 82.6 ng/L, which lies in the middle level of data previously published from other areas in China. The risk quotient (RQ) model was used to evaluate the above data. The results of exposure and risk assessment showed that the margin of exposure (MOE) was 1.28 × 10-2.5 × 10 and the RQ was 0.0266. The European Food Safety Authority (EFSA) standard and categories of RQ indicates that the estimated dietary exposure to TBBPA is unlikely to raise significant health concerns. This is the first report on the occurrence and risk assessment of TBBPA in waters from Xiongan New Area, which will be helpful for further risk assessment of other persistent organic pollutants. At present, the toxicological data of TBBPA in the biological body of Baiyang Lake is limited. In addition, more accurate and convenient approaches for the risk assessment of TBBPA should be explored.
采用气相色谱-质谱法（GC-MS）对雄安新区水中的四溴双酚 A（TBBPA）进行了测定，并对其进行了风险评估。通过正交试验确定了最佳的提取条件、衍生化因子（如衍生试剂用量、衍生化时间和温度）和溶解溶剂。结果表明，最佳衍生化时间和温度分别为 70°C 和 30min，衍生试剂（N，O-双（三甲基硅基）三氟乙酰胺）的用量为 40μL。当使用 6g/L 盐浓度的正己烷-二氯甲烷（1:1，v:v）混合物时，可获得最佳的提取效率。使用 S9 作为对照进行回收实验，在三种不同的加标水平下进行。用优化后的条件分析了白洋淀和府河的水样。结果表明，样品中 TBBPA 的浓度范围为 18.5ng/L 至 82.6ng/L，处于中国其他地区先前公布数据的中间水平。采用风险商（RQ）模型对上述数据进行评价。暴露和风险评估结果表明，暴露边际（MOE）为 1.28×10-2.5×10，RQ 为 0.0266。欧洲食品安全局（EFSA）标准和 RQ 类别表明，估计的 TBBPA 膳食暴露量不太可能引起重大健康问题。这是雄安新区水中 TBBPA 发生和风险评估的首次报道，将有助于进一步评估其他持久性有机污染物的风险。目前，白洋淀生物体中 TBBPA 的毒理学数据有限。此外，应探索更准确和方便的 TBBPA 风险评估方法。
