Wu M X, Chen X F, Zhang H M, Yang H
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2020 May 26;100(20):1551-1556. doi: 10.3760/cma.j.cn112137-20200226-00459.
To evaluate the sleep status and the correlation of sleep status with inflammatory bowel disease (IBD). A case-control study was carried out, including 568 IBD patients including 188 ucerative colitis (UC) patients and 380 Crohn's disease (CD) patients at 36 hospitals from January 1, 2018 to August 31, 2019, and 671 family members and healthy controls from the same cities. The survey consisted of three parts including general demographic data, clinical characteristics and sleep related factors by questionnaires. The items for sleep related factor included sleep duration on work days, sleep duration on weekends, sleep quality, sleep adequacy, snoring, sleep apnea and sleep hand foot movement. R language was used for propensity score and SPSS was used for statistical analysis. The proportion of poor sleep quality before onset in UC and CD was higher than that in healthy control group (CD: 14.5% vs 5.3%, 0.001; UC: 15.1% vs 5.4%, 0.001). In CD group, the proportion of snoring before onset (31.3% vs 44.3%, 0.001) and apnea (0.9% vs 5.5%, 0.001) was lower than that in heathy control group. The proportion of athetosis in CD was higher than that in healthy control group (35.4% vs 28.9%, 0.045). Patients with UC and CD have poor sleep quality before the onset of the disease, especially in CD patients.
评估睡眠状况以及睡眠状况与炎症性肠病（IBD）的相关性。进行了一项病例对照研究，纳入了2018年1月1日至2019年8月31日期间36家医院的568例IBD患者，其中包括188例溃疡性结肠炎（UC）患者和380例克罗恩病（CD）患者，以及来自同一城市的671名家庭成员和健康对照者。该调查由三部分组成，包括通过问卷收集的一般人口统计学数据、临床特征和睡眠相关因素。睡眠相关因素的项目包括工作日睡眠时间、周末睡眠时间、睡眠质量、睡眠充足度、打鼾、睡眠呼吸暂停和睡眠时手足运动。使用R语言进行倾向评分，使用SPSS进行统计分析。UC和CD发病前睡眠质量差的比例高于健康对照组（CD：14.5%对5.3%，P=0.001；UC：15.1%对5.4%，P=0.001）。在CD组中，发病前打鼾的比例（31.3%对44.3%，P=0.001）和呼吸暂停的比例（0.9%对5.5%，P=0.001）低于健康对照组。CD组手足徐动症的比例高于健康对照组（35.4%对28.9%，P=0.045）。UC和CD患者在疾病发病前睡眠质量较差，尤其是CD患者。
