Institute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
J Proteome Res. 2020 Aug 7;19(8):3011-3021. doi: 10.1021/acs.jproteome.0c00049. Epub 2020 Jun 3.
Diabetes mellitus (DM) can cause systemic metabolic disorders, but the impact of gender on DM-related metabolic changes is rarely reported. Herein, we analyzed metabolic alterations in the heart, liver, and kidney of male and female mice from normal to diabetes via a H NMR-based metabolomics method and aimed to investigate sex-specific metabolic mechanisms underlying the onset and development of diabetes and its complications. Our results demonstrate that male mice had more significant metabolic disorders from normal to diabetes than female mice. Moreover, the kidney was found as the major organ of metabolic disorders during the development of diabetes, followed by the liver and heart. These altered metabolites were mainly implicated in energy metabolism as well as amino acid, choline, and nucleotide metabolism. Therefore, this study suggests that the kidney is the primary organ affected by diabetes in a sex-specific manner, which provides a metabolic view on the pathogenesis of diabetic kidney diseases between genders.
糖尿病（DM）可引起全身代谢紊乱，但性别对 DM 相关代谢变化的影响鲜有报道。本研究采用基于 1H-NMR 的代谢组学方法分析了正常至糖尿病雄性和雌性小鼠心脏、肝脏和肾脏的代谢变化，旨在研究性别特异性代谢机制在糖尿病及其并发症发生和发展中的作用。结果表明，从正常到糖尿病，雄性小鼠的代谢紊乱比雌性小鼠更为显著。此外，研究还发现，在糖尿病发展过程中，肾脏是代谢紊乱的主要器官，其次是肝脏和心脏。这些代谢物主要与能量代谢以及氨基酸、胆碱和核苷酸代谢有关。因此，本研究表明，肾脏是糖尿病以性别特异性方式影响的主要器官，为性别间糖尿病肾病的发病机制提供了代谢角度的认识。
