The Department of Ecology, Evolution & Behavior, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
Curr Top Dev Biol. 2020;139:297-324. doi: 10.1016/bs.ctdb.2020.02.004. Epub 2020 May 11.
The Drosophila blastoderm gene regulatory network is one of the best studied networks in biology. It is composed of a series of tiered sub-networks that act sequentially to generate a primary segmental pattern. Many of these sub-networks have been studied in other arthropods, allowing us to reconstruct how each of them evolved over the transition from the arthropod ancestor to the situation seen in Drosophila today. I trace the evolution of each of these networks, showing how some of them have been modified significantly in Drosophila relative to the ancestral state while others are largely conserved across evolutionary timescales. I compare the putative ancestral arthropod segmentation network with that found in Drosophila and discuss how and why it has been modified throughout evolution, and to what extent this modification is unusual.
果蝇胚胎基因调控网络是生物学中研究得最好的网络之一。它由一系列分层的子网组成，这些子网依次作用，产生初级的节段模式。其中许多子网已经在其他节肢动物中进行了研究，使我们能够重建它们在从节肢动物祖先过渡到今天在果蝇中看到的情况时是如何进化的。我追踪了这些网络中的每一个的进化，展示了其中一些在果蝇中相对于祖先状态有了显著的改变，而另一些则在进化时间尺度上基本保持不变。我将假定的祖先节肢动物分割网络与在果蝇中发现的网络进行了比较，并讨论了它在进化过程中是如何以及为什么被改变的，以及这种改变在多大程度上是不寻常的。
