Hodgkinson G I, Everall J D, Smith H V
Br J Dermatol. 1977 Apr;96(4):357-66. doi: 10.1111/j.1365-2133.1977.tb07129.x.
The immunofluorescent patterns in the skin of eighteen patients with Besnier's prurigo were studied at different stages of eczematous lesions. The presence, distribution pattern, and numbers of immunoglobulin and complement-positive lymphocytes in twenty-nine biopsies are reported. In all cases IgE-positive lymphocytes were present in both clinically uninvolved and involved skin. IgG, IgM and IgE-positive lymphocytes showed a characteristic distribution pattern in the dermis. In the acute stages IgM deposition was prominent in the basement membrane zone and it is suggested that damage to the basement membrane results in diffusion of immunoglobulin and complement into the epidermis. These features were not present in a control group of normal skin and of other dermatoses.
对18例贝氏痒疹患者在湿疹性皮损不同阶段的皮肤免疫荧光模式进行了研究。报告了29份活检标本中免疫球蛋白和补体阳性淋巴细胞的存在、分布模式及数量。在所有病例中，IgE阳性淋巴细胞在临床未受累及受累皮肤中均有存在。IgG、IgM和IgE阳性淋巴细胞在真皮中呈现出特征性分布模式。在急性期，IgM沉积在基底膜带显著，提示基底膜损伤导致免疫球蛋白和补体扩散至表皮。这些特征在正常皮肤和其他皮肤病的对照组中不存在。
