Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA, 02114, USA.
Department of Radiology, University of Washington, UWMC Radiology RR218, 1959 NE Pacific St, Seattle, WA, 98195, USA.
Abdom Radiol (NY). 2020 Sep;45(9):2624-2636. doi: 10.1007/s00261-020-02531-5.
Immunotherapy is a rapidly growing field within oncology and is being increasingly used in the management of several malignancies. Due to their unique mechanism of action on the immune system and neoplastic cells, the response pattern and adverse events of this novel therapy are distinct from conventional systemic therapies. Accordingly, the imaging appearances following immunotherapy including adverse events are unique and at times perplexing. Imaging is integral to management of patients on immunotherapeutic agents and a thorough understanding of its mechanism, response patterns and adverse events is crucial for precise interpretation of imaging studies. This review provides a description of the mechanism of action of current immunotherapeutic agents and the organ-wise description of their side effects.
免疫疗法是肿瘤学领域的一个快速发展领域，越来越多地用于治疗多种恶性肿瘤。由于其对免疫系统和肿瘤细胞的独特作用机制，这种新型疗法的反应模式和不良反应与传统的全身治疗不同。因此，免疫治疗后的影像学表现包括不良反应都是独特的，有时甚至令人困惑。影像学检查是免疫治疗患者管理的重要组成部分，深入了解其作用机制、反应模式和不良反应对于准确解读影像学研究至关重要。本文综述了目前免疫治疗药物的作用机制及其器官特异性副作用的描述。
