Internal Medicine Department, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.
Nephrology Department, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.
Hemodial Int. 2020 Jul;24(3):359-366. doi: 10.1111/hdi.12846. Epub 2020 May 25.
Irritable bowel syndrome (IBS) is a functional bowel disease that is common in society, does not threaten life, impairs quality of life, and causes serious economic losses. Gastrointestinal system complaints and especially IBS are common in patients with chronic kidney disease. It has also been shown that psychiatric diseases are more common in patients with IBS. In this study, we aimed to determine the frequency of IBS in hemodialysis patients and to investigate the factors associated with IBS.
In this cross-sectional study, the questionnaire prepared to evaluate depression, anxiety, and abdominal pain was administered face-to-face to 686 patients by the same researcher in seven dialysis centers; 404 patients without exclusion criteria were included in the study. The diagnosis of IBS was made according to Rome IV criteria. A multivariate logistic regression model was used to identify factors that are significantly related to IBS.
In 69 (17.1%) of the patients included in the study, symptoms were consistent with IBS. Binominal logistic regression analysis was performed to evaluate the effect of age, dialysis duration, diabetes, proton pump inhibitor, non-steroidal anti-inflammatory drugs, calcium acetate use, Hamilton depression and anxiety scores associated with IBS in the presence of IBS of the participants. The logistic regression model was statistically significant, χ (3) = 69.748, P < 0.001. Independent risk factors for IBS in hemodialysis patients were determined as anxiety, long-term dialysis treatment, and using calcium acetate as a phosphorus binder.
In hemodialysis patients, IBS occurs approximately twice as often as in a healthy population. Independent risk factors for IBS in hemodialysis patients are anxiety, long-term dialysis treatment, and using calcium acetate as a phosphorus binder.
肠易激综合征（IBS）是一种常见于社会的功能性肠病，它不会威胁生命，却会降低生活质量，并造成严重的经济损失。胃肠道系统的不适，尤其是 IBS，在慢性肾脏病患者中很常见。此外，也有研究表明，IBS 患者更容易患有精神疾病。在这项研究中，我们旨在确定血液透析患者中 IBS 的发病率，并探讨与 IBS 相关的因素。
在这项横断面研究中，由同一位研究者在七个透析中心通过面对面的方式向 686 名患者发放了评估抑郁、焦虑和腹痛的问卷，共有 404 名符合排除标准的患者纳入研究。根据罗马 IV 标准诊断 IBS。采用多变量逻辑回归模型来确定与 IBS 显著相关的因素。
在纳入研究的 69 名（17.1%）患者中，症状符合 IBS。为了评估参与者中 IBS 的年龄、透析时间、糖尿病、质子泵抑制剂、非甾体抗炎药、醋酸钙使用、汉密尔顿抑郁和焦虑评分与 IBS 的关系，进行了二项逻辑回归分析。逻辑回归模型具有统计学意义，χ²（3）=69.748，P<0.001。血液透析患者患 IBS 的独立危险因素为焦虑、长期透析治疗和使用醋酸钙作为磷结合剂。
在血液透析患者中，IBS 的发病率约为健康人群的两倍。血液透析患者患 IBS 的独立危险因素为焦虑、长期透析治疗和使用醋酸钙作为磷结合剂。
