Schmidt U, Senf L, Preu E
Klinik für Innere Medizin, Medizinischen Akademie Erfurt.
Z Gesamte Inn Med. 1988 Dec 1;43(23):680-4.
Conventional ferrokinetic studies were done in patients with idiopathic hemochromatosis, secondary siderosis of the liver and iron overload in consequence of sideroblastic or aplastic anaemia. By means of the isotope 59Fe we determined the clearance of radioiron from the plasma, the plasma iron turnover, the utilization of iron by the erythropoesis and the iron uptake by the liver. The later value showed a good correlation with the iron content of the liver determined by atomic absorption spectrometry as well in patients with hemochromatosis as in patients with secondary siderosis of the liver. The 59Fe uptake by the liver was normal in treated hemochromatosis. There was no correlation between the degree of the iron overload and the 59Fe uptake by the liver in patients with anaemia.
对患有特发性血色素沉着症、继发性肝铁质沉着症以及由于铁粒幼细胞性贫血或再生障碍性贫血导致铁过载的患者进行了传统的铁动力学研究。借助同位素59Fe，我们测定了血浆中放射性铁的清除率、血浆铁周转率、红细胞生成对铁的利用率以及肝脏对铁的摄取。在血色素沉着症患者和继发性肝铁质沉着症患者中，后一数值与通过原子吸收光谱法测定的肝脏铁含量显示出良好的相关性。经治疗的血色素沉着症患者肝脏对59Fe的摄取正常。在贫血患者中，铁过载程度与肝脏对59Fe的摄取之间没有相关性。
