Langevin-Perriat A, Lafont S, Vincent C, Revillard J P, Mazert M C, Gerfaux G, Tron F
Laboratory of Immunology, INSERM U80 UA 1177 UCBL, Hôpital E. Herriot, Lyon, France.
Vaccine. 1988 Dec;6(6):509-12. doi: 10.1016/0264-410x(88)90102-8.
The ability is reported of a new oral cholera vaccine composed of Vibrio cholerae antigenic fractions to induce a serum and mucosal antibody response after three oral administrations of microgranules to 18 French volunteers according to different protocols of immunization. Specific antibodies were detected in the three different fluids studied (saliva, jejunal fluid, serum) in one third of volunteers before vaccination. An increase of specific IgA antibody level was observed in jejunal fluids of most volunteers after oral vaccination. An augmentation of specific antibodies against vaccine antigenic components was also observed in serum and in saliva after vaccination but in fewer volunteers.
据报道，一种由霍乱弧菌抗原成分组成的新型口服霍乱疫苗，按照不同免疫方案对18名法国志愿者口服三次微粒后，能够诱导血清和黏膜抗体反应。在接种疫苗前，三分之一的志愿者在研究的三种不同液体（唾液、空肠液、血清）中检测到特异性抗体。口服疫苗后，大多数志愿者的空肠液中特异性IgA抗体水平升高。接种疫苗后，血清和唾液中针对疫苗抗原成分的特异性抗体也有所增加，但涉及的志愿者较少。
