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双氧化酶在生理学和癌症中的作用。

The role of dual oxidases in physiology and cancer.

作者信息

Faria Caroline Coelho de, Fortunato Rodrigo Soares

机构信息

Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, RJ, Brazil.

出版信息

Genet Mol Biol. 2020 May 20;43(1 suppl. 1):e20190096. doi: 10.1590/1678-4685/GMB-2019-0096. eCollection 2020.

Abstract

NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H2O2 generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology.

摘要

NOX/DUOX酶是跨膜蛋白,可通过生物膜传递电子,产生活性氧。NOX家族由七个成员组成,即NOX1至NOX5以及DUOX1和DUOX2。DUOX酶最初因其在甲状腺组织中的高表达水平而被称为甲状腺氧化酶。然而,DUOX在几种甲状腺外组织中也有表达,主要在唾液腺、气道和肠道的顶端膜上,这揭示了与DUOX相关的过氧化氢生成相关的其他细胞功能。在本综述中,我们将简要总结关于DUOX结构和生理功能的现有知识,以及它们在癌症生物学中的可能作用。

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