Institute of Analytical Chemistry, Leipzig University, Linnéstraße 3, 04103, Leipzig, Germany.
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via L. Borsari 46, 44121, Ferrara, Italy.
Chemistry. 2020 Oct 15;26(58):13152-13156. doi: 10.1002/chem.202002063. Epub 2020 Sep 17.
A versatile one-step photopolymerization approach for the immobilization of enantioselective organocatalysts is presented. Chiral organocatalyst-containing monoliths based on polystyrene divinylbenzene copolymer were generated inside channels of microfluidic chips. Exemplary performance tests were performed for the monolithic Hayashi-Jørgensen catalyst in continuous flow, which showed good results for the Michael addition of aldehydes to nitroalkenes in terms of stereoselectivity and catalyst stability with minimal consumption of reagents and solvents.
提出了一种通用的一步光聚合方法，用于固定对映选择性有机催化剂。在手性微流控芯片通道内生成了基于聚苯乙烯二乙烯基苯共聚物的含手性有机催化剂的整体式固定相。对整体式 Hayashi-Jørgensen 催化剂在连续流中的典型性能测试表明，在试剂和溶剂消耗最小的情况下，该催化剂在醛与硝基烯烃的迈克尔加成反应中具有良好的立体选择性和催化剂稳定性。
