Verbitskaia L B, Semenchenko I I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(12):46-8.
In semithin sections of the frontal and temporal cortex from the human brains the compensatory-adaptive changes of neurons and glia were studied. The specimens were obtained from 2 physiologically aged subjects, 7 cases of senile dementia, 2 cases of Alzheimer disease. Alongside with the destructive changes in nerve and glial cells, the compensatory-adaptive processes were detected in aging brains, generally characteristic of the physiologic aging: the nucleolus shift to the nucleus periphery; redistribution of the nuclear chromatin, nuclear membrane invagination; closer attraction of the organelles to nuclear membrane as destruction increased; assembling the neural and glial cells; establishment of the desmosome-like glioglial contacts.
在取自人类大脑额叶和颞叶皮质的半薄切片中，研究了神经元和神经胶质细胞的代偿性适应变化。标本取自2名生理性衰老受试者、7例老年痴呆症患者和2例阿尔茨海默病患者。除了神经和神经胶质细胞的破坏性变化外，在衰老大脑中还检测到了代偿性适应过程，这通常是生理性衰老的特征：核仁向核周边移动；核染色质重新分布，核膜内陷；随着破坏增加，细胞器与核膜的吸引力增强；神经和神经胶质细胞聚集；形成类桥粒的神经胶质细胞间接触。
