Terry R D, Peck A, DeTeresa R, Schechter R, Horoupian D S
Ann Neurol. 1981 Aug;10(2):184-92. doi: 10.1002/ana.410100209.
Image analysis apparatus was used to count and measure glial and neuronal perikarya in ten size classes in the midfrontal region and superior temporal gyrus of 18 patients with senile dementia of the Alzheimer type for comparison with 12 age-matched normal specimens. Brain weight was about 8% less in the dementia group. The major differences had to do with larger neurons, which in dementia were reduced by about 40% in the frontal cortex and 46% in the temporal region. The concentration of neuritic plaques did not correlate significantly with brain weight, cortical thickness, or cell counts.
使用图像分析设备对18例阿尔茨海默型老年痴呆症患者额中部区域和颞上回的胶质细胞和神经元胞体进行计数和测量，并分为十个大小类别，与12个年龄匹配的正常样本进行比较。痴呆组的脑重量约减少8%。主要差异在于较大的神经元，在痴呆症患者中，额叶皮质的此类神经元减少了约40%，颞叶区域减少了46%。神经炎性斑块的浓度与脑重量、皮质厚度或细胞计数无显著相关性。
