香草醛衍生物作为抗菌剂的合成与评价
Synthesis and Evaluation of Vanillin Derivatives as Antimicrobial Agents.
作者信息
Yadav Rakesh, Saini Dharamvir, Yadav Divya
机构信息
Banasthali University, Faculty of Pharmacy, Rajasthan, India.
出版信息
Turk J Pharm Sci. 2018 Apr;15(1):57-62. doi: 10.4274/tjps.97752. Epub 2018 Apr 2.
Abstract
OBJECTIVES
The present work involves the synthesis of novel acetyl vanillin derivatives and evaluation for their anti-microbial potential against .
MATERIALS AND METHODS
The titled compounds were prepared by reacting acetyl nitro vanillin with different substituted amines (Schiff base). The starting material acetyl nitro vanillin was synthesized by reacting acetyl vanillin with fuming nitric acid which in turn was prepared from 4-hydroxy-3-methoxybenzaldehyde (vanillin).
RESULTS
The chemical structures of the synthesized compounds were confirmed on the basis of their spectral data (FT-IR, UV/Visible, H-NMR, Mass spectra).
CONCLUSION
All the synthesized compounds were tested in vitro for antimicrobial activity and compound F & I showed significant activity as compared to the standard drug.
摘要
目的
本研究涉及新型乙酰香草醛衍生物的合成及其对……的抗菌潜力评估。
材料与方法
通过乙酰硝基香草醛与不同取代胺反应（席夫碱反应）制备标题化合物。起始原料乙酰硝基香草醛由乙酰香草醛与发烟硝酸反应合成，而乙酰香草醛又由4-羟基-3-甲氧基苯甲醛（香草醛）制备。
结果
根据光谱数据（傅里叶变换红外光谱、紫外/可见光谱、氢核磁共振光谱、质谱）确定了合成化合物的化学结构。
结论
所有合成化合物均进行了体外抗菌活性测试，与标准药物相比，化合物F和I表现出显著活性。
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