Kumar Rohit, Gupta Nitin, Kodan Parul, Mittal Ankit, Soneja Manish, Wig Naveet
1Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.
2Department of Infectious Diseases, Kasturba Medical College, Manipal, Karnataka 576104 India.
Trop Dis Travel Med Vaccines. 2020 May 20;6:6. doi: 10.1186/s40794-020-00107-1. eCollection 2020.
Coronavirus disease-19 (COVID-19) has reached pandemic proportions. Most of the drugs that are being tried for the treatment have not been evaluated in any randomized controlled trials. The purpose of this review was to summarize the in-vitro and in-vivo efficacy of these drugs on Severe Acute Respiratory Syndrome (SARS-CoV-2) and related viruses (SARS and Middle East Respiratory Syndrome) and evaluate their potential for re-purposing them in the management of COVID-19.
新型冠状病毒肺炎(COVID-19)已发展到大流行程度。目前正在试验的大多数治疗药物尚未在任何随机对照试验中进行评估。本综述的目的是总结这些药物对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)及相关病毒(SARS和中东呼吸综合征)的体外和体内疗效,并评估将它们重新用于COVID-19治疗的潜力。