Wu Jin'en, Yang Jing, Cho William C, Zheng Yadong
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China.
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region.
J Adv Res. 2020 Apr 29;24:317-324. doi: 10.1016/j.jare.2020.04.017. eCollection 2020 Jul.
Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing pathways. As a key player in these pathways, the abnormal expression and/or mis-modifications of Argonaute proteins lead to the disorder of small RNA biogenesis and functions, thus influencing multiply biological processes and disease development, especially cancer. In this review, we focus on the post-translational modifications and novel functions of Argonaute proteins in alternative splicing, host defense and genome editing.
AGO蛋白在几乎所有生物体中都高度保守。它们不仅参与小调节RNA的生物合成，还通过小RNA介导的基因沉默途径调节基因表达并抵御外来病原体入侵。作为这些途径中的关键因子，AGO蛋白的异常表达和/或错误修饰会导致小RNA生物合成和功能紊乱，从而影响多种生物学过程和疾病发展，尤其是癌症。在本综述中，我们重点关注AGO蛋白在可变剪接、宿主防御和基因组编辑中的翻译后修饰及新功能。
